Current Studies


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Amyloidopathy, cholinopathy, dopamine responsiveness and freezing of gait in PD We are looking for adults with Parkinson’s disease who want to participate in a study (“Freezing of Gait Study”) that looks at the availability of certain neurotransmitter systems in the brain and how it relates to freezing of gait. Procedures will include clinical, motor, and neuropsychological testing. The study will also include a brain MRI and PET scans. We are seeking adults with Parkinson’s disease. Subjects may be either male or female, age 50 years or older. You will be compensated for time and effort. https://umhealthresearch.org/#studies/HUM00110351 Yes Parkinson's Disease 
Cholinergic Mechanisms of Gait Dysfunction in Parkinson's Disease The following subjects can participate in this study. Individuals with Parkinson’s disease or Progressive Supranuclear Palsy (PSP). At least 50 years of age. No history of major stroke. Not on medications to treat memory difficulties or hallucinations. Should be able to undergo brain MRI. This study involves the following. Detailed examinations of your mobility functions and thinking skills. This part will take about 1 full day of your time. Brain imaging procedures will be performed on another day, which will also take about 1 full day of your time. For those with Parkinson’s disease, all these study procedures will be repeated at approximately two years after your initial visits. https://umhealthresearch.org/#studies/HUM00093414 Yes Parkinson's Disease 
Clinical Effects of Scalp Cooling in Multiple Sclerosis This study looks at the effect of head cooling on motor- and cognitive -functioning and fatigue in persons with multiple sclerosis. No medications are involved in this study; you will stay on your current therapy. You may be eligible to participate in this study if you are 21-60 years old, have stable multiple sclerosis (with or without disease-modifying therapy) and experience some multiple sclerosis-related motor symptoms on an almost daily base, and other criteria may also apply. You will be compensated for your time and effort. This study involves 4 sub-studies (ranging in duration from 1 day to 1 month and may include neuroimaging procedures). https://umhealthresearch.org/#studies/HUM00109116 Yes Multiple Sclerosis 
Effects of dynamic standing vs. static standing on subjective fatigue symptoms: a pilot study We are looking for persons who want to participate in a study that will look at the effects that performing light office work while standing upright will have on subjective ratings of muscle comfort. Tests will include upright standing behind a desk, quietly or while making small stepping movements, and various questionnaires. We are seeking healthy adults without a medical history that would prevent from safe participation in the project. Subjects may be either male or female, ages 20-50. Participants will be compensated for time and effort.  Yes Healthy Controls, Parkinson's Disease, and Multiple Sclerosis 
Lewy Body Dementia Biomarkers In cooperation with the US Public Health Service, National Institutes of Health are conducting a research study to learn more about conditions related both to Parkinson disease (PD) and difficulty with memory and concentration, called dementia. Patients usually have combinations of several brain changes, including the accumulations of proteins in nerve cells called synuclein (Syn), or of proteins in nerve cells called tau, or of proteins outside of brain cells called a-beta-amyloid (AB). Individual patients may have a combination of these changes, but at present, doctors have no way of knowing which specific changes a patient has. Dementia associated with PD has no effective treatment at the present time, and to develop new therapies it is believed that knowing the specific changes in individual patients will be required. This research project will investigate new brain imaging approaches that the investigators hope will identify protein accumulations in the brain of individual patients with PD-related dementia. Investigators will also collaborate with the US National Institutes of Health in establishing a national research database including data on PD and dementia ratings, brain scans, and samples of blood, spinal fluid and DNA to enhance and accelerate future investigations of the PD and dementia disorders. https://pdbp.ninds.nih.gov/Lewy-Body-Dementia-Biomarkers-U01 Yes Dementia with Lewy Body and Parkinson's Disease Dementia 
Modulation of GABA-A Receptors and Axial Motor Impairments in Parkinson Disease This study looks at the effect of two different types of medication on participants’ balance and walking abilities. These medications are currently approved by the FDA for different use. This study involves the following. Detailed examinations of your balance and walking abilities and brain imaging procedures. All participants will undergo these examinations and will be conducted over several days. Some patients will receive an i.v. injection with one of these two medications (or an inactive ingredient). Balance and walking abilities will be examined at different times immediately before and after the injection. This sub-study will require 2 extra visits. Other patients will receive the other medication (or an inactive ingredient), which is a pill you will take for a week. Repeat balance and walking abilities will be examined on the day you start the pill and again 7 and 14 days after you start taking this pill. An extra brain scan will be also taken after 1 week. This sub-study will require 3 extra visits. Compensation up to $1150. https://umhealthresearch.org/#studies/HUM00130361 Yes Parkinson's Disease 
Peripheral neuromuscular facilitation of ambulatory functions in patients with gait disturbances We are looking for persons who want to participate in a study that will look at the effects of a dynamic gait training device on walking capabilities. Tests will include walking, turning, small stepping movements, and various questionnaires. We are seeking adults with Parkinson’s disease, Huntington’s disease, multiple sclerosis, neuropathy, slow walking, or stroke to participate in the project. Subjects may be either male or female, ages 18 years and older. Participants will be compensated for time and effort.  Yes Parkinson’s disease, Huntington’s disease, multiple sclerosis, neuropathy, slow walking, or stroke 
Post-PT Extension of In-Home Dynamic Standing Table Use in Parkinson Disease This study is for people with Parkinson’s disease. We are looking for participants above 45 years old, male and female, who are able to stand unassisted. We are studying the effects of using a dynamic standing table at home to maintain the benefits of 12 sessions of physical therapy on balance, gait, and overall physical activity. A dynamic standing table has a tabletop that moves side to side as you stand behind it. It moves at a slow constant speed and is designed to serve as a non-exercise physical activity while you perform routine desktop activities. We are investigating whether it could be a low effort solution to preserve the significant short-term benefits found from Parkinson’s patients participating in physical therapy. Participation lasts about 23 weeks. You will be compensated for your time and effort. https://umhealthresearch.org/#studies/HUM00118467 Yes Parkinson's Disease 
The effects of scalp cooling on recovery time from mental fatigue We are looking for healthy adults who want to participate in a research study that looks at the effect of scalp cooling on recovery time from mental fatigue. Subjects may be either male or female, age 18-60 years. You will be compensated for time and effort. https://umhealthresearch.org/#studies/HUM00099671 No Healthy Controls 
Showing 9 items